Yes. Copy the desktop WooPOS icon, right-click to change properties.
Add this at end of target line:
Instance WooPOSCosmeticLabs 1799
Instance WooPOS2 1799
In this case, CosmeticLabs is the business name, 1799 is SQL TCP/IP port.
Double click this icon on the desktop, follow WooPOS setup wizard to start the second business setup. Please use a different Email account in the setup.